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Calcium alpha-ketoglutarate molecular science illustration
28
MAY2026

Aging Cell

FeaturedPress Release

Rejuvant Outperforms All Other Supplements, Including Standard AKG and NAD+ in Landmark Aging Cell Study

Ponce De Leon Health highlights publication of a landmark peer-reviewed study in Aging Cell showing Rejuvant is associated with an average 1.8 year lower age residual — the only supplement to achieve statistical significance among 84 tested.

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Earlier Coverage · 21 of 22

03DEC 2021
Press ReleaseGlobeNewsWire

Study Shows Rejuvant Decreases Biological Age By Eight Years in Seven Months

A randomized retrospective study of 42 individuals published in Aging shows Rejuvant, a patent-pending, timed-release CaAKG (calcium alpha-ketoglutarate) plus vitamin A for men and vitamin D for women, decreases biological age by an average of eight years after approximately seven months.

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01DEC 2021
ResearchAging (Journal)

Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test

The search continues for possible interventions that delay and/or reverse biological aging, resulting in extended healthspan and lifespan. Interventions delaying aging in animal models now lead us to evaluate their potential in humans.

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14MAY 2021
Press ReleaseNew York Times

Can We Live to 200?

In the last century, the average human life expectancy doubled. Here's a roadmap to the innovations that could help us do it again - maybe. Rejuvant is the only commercially available product with data showing a positive effect on healthspan and lifespan.

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15SEP 2020
Press ReleaseAesthetic Authority

Healthy Aging from the Inside Out

A recent study suggests calcium alpha-ketoglutarate could positively affect aging, with increases in lifespan, a reduction in frailty, and increase in healthspan.

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15SEP 2020
Press ReleaseMD News Daily

Dietary Supplement Found To Promote Healthy Aging and Increased Life Span

MD News Daily reports on the dietary supplement Rejuvant, found to promote healthy aging and increased life span in the landmark Buck Institute study - the first evidence of a non-drug ingredient achieving this result in mammals.

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15SEP 2020
ResearchScience Magazine

Bodybuilding supplement promotes healthy aging and extends life span, at least in mice

Science Magazine covers the landmark Buck Institute study showing that alpha-ketoglutarate, a compound used by bodybuilders, promotes healthy aging and extends life span in mice.

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PDLH - Researching the Future of Healthspan